DR. ANUPRIYA CHAUBEY

DR.SOMNATH DE, DR. SANDEEP SAXENA

Abstract

Aim: To study the changes in quantitative,cross-sectional and topographic parameters on SD OCT post intra vitreal bevacizumab therapy (IVB) in diabetic macular edema(DME).Method:44 consecutive patients aged 40-65 years having type 2 diabetes mellitus with DME were prospectively recruited for IVB comprising of 3 doses (1.25mg in 0.05ml) at monthly interval.Visual acuity (LogMAR) was recorded.SD OCT was performed.Changes in central sub-foveal thickness (CST),grades of disorganization of retinal inner layers (DRIL) and grades of retinal pigment epithelium alterations (RPE-A) post IVB therapy were assessed.Results:Mean log MAR VA decreased after IVB regimen from 1.78 ± 0.07 to 0.42 ± 0.05.CST reduced from 355 ±15.0 µm to 233 ± 8 µm,DRIL reduced from 86% to 14% and RPE-A observed in 4 quadrants reduced significantly.Conclusion: Anti-VEGF therapy has significant impact in reduction of quantitative, cross-sectional and topographic parameters as well as associated improvement in VA in DME.