Dr. ANASUA GANGULY

DR. V S VIJITHA, DR. SWATHI KALIKI, DR. ARAVIND ROY

Abstract

Retrospective case-control study in which 20/939 eyes (2%) with OSSN and MK were included in the study group and 100 age-matched eyes with only OSSN as controls. Mean corneal surface involvement by MK was 48% with corneal perforation in 6 (30%) cases. Microbiology showed 10 culture positive cases for gram positive organisms (n=5), fungus (n=4) or mixed infection (n=1). In the salvaged eyes, MK resolved in 9 (90%) on medical treatment at a mean duration of 30 days and keratoplasty was performed in 1. OSSN treatment included wide excisional biopsy (n=9/18; 50%), extended enucleation (n=7/18; 39%) and orbital exenteration in 1. Over a mean follow-up of 12 months, vision salvage was achieved in 7/18 (39%) and globe salvage in 10/18 (55%). Male gender, HIV seropositivity, large limbal pigmented OSSN lesion with keratin and corneal component, nodulo-ulcerative morphology, scleral invasion were risk factors for this association on logistic regression analysis.