DR. NEHA SHAH

DR. PURVA VALVEKAR, DR.SAROJ SAHDEV, DR.SWATI HIRE

Abstract

Purpose: To investigate retinal changes prior to vascular signs in patients with diabetes without diabetic retinopathy or with mild NPDR. The central ganglion cell-inner plexiform layer (GCIPL) thickness and the parapapillary retinal nerve fibre layer (RNFL) thickness between the 2 groups.

Methods: In this comparative case-control study two groups of 150 eyes were examined objectively with SD-OCT Macular cube scans were analysed with regard to: the GCIPL analysis and optic disc RNFL analysis. The first group includes 100 eyes of diabetic patients the second group included 50 eyes of non-diabetic, non-glaucomatous patients.

Results: The two groups were matched concerning the age, gender. A significant differences between the groups was found for the RNFL thickness. Concerning the GCIPL thickness, it was significantly less in the diabetic eyes.

Conclusion: RNFL and GCIPL loss seems to be the earliest retinal changes in diabetic patients, and associated with diabetic duration.