DR. AASHNA DOSHI

DR. PARTHAPRATIM DUTTA MAJUMDER, DR. JYOTIRMAY BISWAS

Abstract

Management of HLA B27 associated uveitis in presence of latent or active tuberculosis (TB) remains a challenge. We conducted a retrospective chart review of patients who were HLA B27 positive and had evidence of TB. Our study included 13 eyes of 7 patients of which 7 eyes (53.85%) presented with anterior uveitis, 2 eyes (15.38%) had both anterior and intermediate uveitis and 4 eyes (30.77%) had panuveitis. The mean age of presentation was 34.14 ± 9.06 years and 6 patients (85.71%) had bilateral involvement. Mantoux test was positive >15mm in 5 patients (71.43%) while the other 2 patients had pulmonary TB. Two patients (28.57%) were diagnosed as ankylosing spondylosis, 2 (28.57%) gave history of multiple joint pain, 1 had cervical spondylosis. ATT was administered for 4 patients (57.14%) and 3 patients (28.57%) were advised immunosuppressives. Patients with HLA B 27 associated uveitis should be screened for TB and managed carefully in presence of latent or active TB.