DR. FARHEENA KULSUM

DR. PRANAV KANSAL, DR.SIMI ZAKA-UR-RAB, DR. MOHAMMAD AZIMUDDIN MALIK

Abstract

93 patients were taken in group A(60)–patients with diseases of posterior segment of the eye and group B (33)–healthy controls. Exclusion criteria:Systemic inflammatory disease,autoimmune disease,laser photocoagulation, intraocular surgery or steroids or vitamin D intake in the past 3 months. Fasting blood plasma were collected. VEGF, PEDF and vitamin D estimation was done using ELISA kits. Group A had patients with diabetic retinopathy(38.89%), retinal vein occlusion(19.44%), age-related macular degeneration(16.67%), uveitis(13.89%) and Eales disease(11.11%).Vitamin D was significantly lower in A than in B(p<0.001). VEGF was significantly higher in A than in B(p<0.001). It was negatively correlated with vit D(p<0.001).PEDF was significantly higher in A than in B(p=0.003). It was negatively correlated with vit D(p=0.002). Thus increase in angiogenic cytokines(VEGF PEDF) indicating the microvascular damage can be decreased with the anti angiogenic property of vitamin D