DR. MD. SHAHID ALAM

DR. PRABRISHA BANERJEE, DR. MD. SHAHID ALAM

Abstract

Aim: To evaluate the effect of direct cell injury of cryotherapy on eyelid sebaceous gland carcinoma (SGC) cells by an ex-vivo cryotherapy experiment. Methods: It was a prospective interventional case series. Six patients with biopsy-proven SGC were included. After excision of the mass, a thin slice of the mass was shaved off and was oriented over the broad end of a tissue forceps. Cryotherapy was applied by the triple freeze-thaw technique. The mass was then labeled and sent separately for histopathological evaluation.

Results: A total of six patients with a mean age of 58.2 ± 15.5 years were included. There were 4 females and 2 males. There was no regional lymphadenopathy or metastasis in any of the cases. The experimental cryo-tissue containing the cryo-treated lesion revealed the presence of viable tumor cells in all. Conclusion: The direct cell injury caused by cryotherapy may not be good enough to ensure tumor cell-free tumor bed.