DR. REBIKA

DR. ROHIT SAXENA, DR. ASMITA MAHAJAN, DR. SWATI PHULJHELE

Abstract

Involvement of retinal ganglionic cells is well established in optic neuropathies, but that of photoreceptor layer is debatable. The aim of this cross-sectional study is to examine the cone mosaic characteristics in optic neuropathies using adaptive optics (AO) and compare with age-matched controls. Apart from anterior and posterior segment evaluation, colour vision, contrast sensitivity, visual field, fundus OCT and AO retinal imaging using rtx1 retinal camera (Imagine Eyes; Paris, France) was done. This is an ongoing study.

16 eyes of 16 patients (8 glaucomatous and 8 non-glaucomatous optic neuropathy) are enrolled till date. Preliminary results show significantly lesser cone mosaic density (P=0.001) and cone regularity (P=0.004), significantly increased cone spacing (P=0.016) and dispersion (P=0.011) and significantly reduced NN6 % (P=0.006) in optic neuropathies compared to the age-matched controls. This confirms cone photoreceptor involvement along with inner retinal changes.