DR. VIVEK ARAVIND

DR.SUKHADA MISHRA, DR.UTTAM PRAKASH, DR. MANASI NAYAK

Abstract

Objectives:Comparison of pre and post treatment ulcer size or depth and cell infiltrates, BCVA over a follow-up period of one month.Methodology:We designed a prospective interventional clinical study.All patients with fungal keratitis proven by presence of fungal filaments on smear and/or culture, not responding to topical natamycin (5%) and and oral itraconazole therapy for 2 weeks were included.Result:62 out of 84 cases in our study population has shown complete resolution of non responding fungal keratitis after treatment with intrastromal voriconazole injection. There was no complication during procedure.Conclusion:Intrastromal injection of voriconazole might be used as an adjunct for non responding fungal keratitis in selected patients.Ulcer depth till mid stroma showed higher resolution.Epithelial defect size and stromal infiltrate size has a correlation with efficacy of intrastromal injection of voriconazole.A cost effective method of providing higher concentration of the drug.