MRS.DR.RITIKA

DR. SHRIKANT, DR. DEEPAK MISHRA, DR. TANMAY SRIVASTAV

Abstract

AIM:To evaluate the role of Thr715Pro P-Selectin gene polymorphism in patients with Diabetic Retinopathy in North Indians.

Methods: This was prospective clinical study conducted on 60 patients.They were categorised equally in three groups namely Diabetics with diabetic retinopathy (DwDR), Diabetics without diabetic retinopathy (DwoDR), and non diabetics. The non-diabetics group was further divided into healthy controls, Hypertensive Retinopathy (HR) and Non-exudative Age Related Macular Degeneration (NEAMD).Blood samples were drawn for genetic study with their informed consent.

Results: The genotypic analysis showed that Thr715Pro (A/C) polymorphism prevalence was significantly high in DwDR (p = 0.003) and DwoDR (p = 0.003) compared to healthy controls.No significant difference was noted between DwDR, DwoDR and the HR and NEAMD groups.

Conclusion: Thr715Pro P-Selectin gene Polymorphism could not be established as an independent factor in the pathogenesis of diabetic retinopathy.