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  5. FP1583 : Correlation of Risk Factors & Adjuvant Therapy in the Era of Secondary Enucleation in Retinoblastoma

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DR. ROLIKA BANSAL

Dr. FAIROOZ PUTHIYAPURAYIL MANJANDAVIDA, Dr. KAUSTUBH MULAY, Dr. SANTOSH G. HONAVAR

Abstract

Purpose:Chronicity of retinoblastoma increases the clinical risk factors(CRF) &amp; histopathological risk-factors(HRF). We assessed their corelation in predicting risk of metastasis.Methods:Retrospective interventional consecutive case series Results:Of 406 eyes after secondary enucleation, 122(30%) had HRF. At baseline, CRF in 91(75%) included iris neovascularization40(33%),secondary glaucoma39(32%),sterile orbital inflammation32(26%) &amp; anterior chamber seeds22(18%). Median 6 cycles of chemotherapy were given before enucleation. HRF were infiltration of iris19(16%),ciliary body26(21%),choroid(>3 mm)56(46%);optic nerve retrolaminar18(15%) &amp; resected end8(7%); scleral lamellar42(34%) &amp; extrascleral13(11%). Adjuvant chemotherapy given in all &amp; radiotherapy in 10(8%). Presence of CRF correlated with HRF, p<0.001. Life salvage was in 116(95%) at 120+79m followup.Conclusion:Corelation of CRF&amp;HRF,helps in predicting metastasis &amp; timely treatment provides better prognosis &amp; promotes life salvage

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