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  5. FP2012 : Pain protocol in PRK and CXL: Cold to the rescue

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Dr. Gairik Kundu

DR. SAILIE SHIRODKAR, Dr. ROHIT SHETTY, Dr. POOJA KHAMAR

Abstract

Purpose: To compare post-operative analgesic effects rendered by the use of cold & room temperature (RT) bandage contact lenses (BCLs) post photorefractive keratectomy (PRK) & crosslinking (CXL) & to identify molecular factors associated with it

Methods: 249 keratoconus eyes advised CXL & 135 normal eyes advised PRK, were grouped into 4 as per BCL: Conventional (BCLs at RT), Conventional+KT (RT & 0.4% ketorolac tromethamine), Cold (BCLs at 4⁰C) & Cold+KT (4⁰C & 0.4% KT). Pain was graded by Wong-Baker scale. Molecular profiling in tear samples & BCLs was also performed.

Results: Cold &amp; Cold+KT had significantly (P<0.0001) low pain scores compared to Conventional &amp;/or Conventional+KT in CXL &amp; PRK patients. Significant differences in expression of nociception associated genes in those with low &amp; high scores were noted. Conclusion: This simple &amp; economical approach promises to be effective in controlling post-operative pain &amp; increase patient comfort with no delay in epithelial healing.

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