Dr. SUNIL GANEKAL

Dr. SACHIN MAHULI

Abstract

Purpose- Efficacy of fluorescein-assisted subretinal tPA during vitrectomy for submacular hemorrhage

Methods-Prospective study of 18 eyes of 18 patients undergoing PPV with fluorescein-assisted subretinal tPA for submacular hemorrhage. Out of 18 patients, 10 had wet AMD and 8 had PCV. All patients underwent standrard 23 guage vitrectomy. 2 mL tPA (concentration:25 mg/0.1 mL) poured into a standard silicone oil syringe with attached 41-gauge cannula. A sterile fluorescein sodium strip was placed into the tPA creating an orange solution. Using vitrectomy system slow trickle of flourescein tPA injected into subretinal space. Post operatively assessed for successful postoperative displacement of submacular hemorrhage and change in visual acuity from baseline.

Results-Overall, 9/18 eyes gained visual acuity, 8/18 eyes remained stable, and 1/18 eyes lost VA.

conclusion-Fluorescein-assisted delivery of subretinal tPA improved visualization of subretinal tPA without toxicity or complications

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