DR. AKANKSHA SAHU

DR.(MAJ) SHANKAR SANDEEP, DR. ASHOK KUMAR, DR.SRUJANA D

Abstract

Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare autoimmune chronic inflammatory disease involving Central nervous system. The detection of anti-myelin oligodendrocyte Antibody (Anti-MOG-Ab) is emerging evidence in NMOSD thus research on the role of this entity in Aquaporin-4 (AQP-4) seronegative cases is still underway.

Here we report two cases of NMOSD who presented with profound vision loss, found to have full-blown optic neuritis and suspicion of acute myelitis clinically. An urgent MRI revealed demyelinating disease. He was referred to the pediatrician and neuro-physician immediately. On further evaluation, they were detected with Anti-MOG Ab positive instead of AQP-4-Ab. Treatment included steroids, IVIG and Rituximab with intense rehabilitation following which remarkable recovery was seen and the vision improved upto 6/9.

Conclusion: NMO is a demyelinating condition that causes severe visual loss. Prompt identification management may lead to a favorable visual outcome.