DR. SANCHARI SARKAR

DR. SANJAY KUMAR DAULAT THAKUR, DR. AVIK DEY SARKAR, DR. PAYEL KHATUA

Abstract

Aim: To assess the response of Intravitreal Ranibizumab (IVR) on Spectral Domain Optical Coherence Tomography (SD-OCT) Biomarkers in patients of Retinal Vein Occlusion (RVO). Methods: A prospective study was conducted among 64 patients of RVO, who were treated with IVR. SD-OCT was done before starting treatment and then at 1, 3 and 6 months respectively to analyze the changes in biomarkers following treatment. Results: Average reduction in Central macular thickness (CMT) and visual gain was 300.20±171.31µm and 4.32 lines in Snellen`s chart respectively. Average dimension of centre involving cystic space reduced by 68%(p=0.004). Average Subretinal fluid (SRF) height reduced by 74%(p=0.0008). Hyperreflective Foci scores reduced by 9%. 37% patients ended up with Epiretinal membrane. 45% patients had persistent external limiting membrane and ellipsoid zone disruption. Conclusion: Besides significant visual gain, IVR has role in decreasing CMT and resolution of cystic spaces and SRF.