Dr.ADHIKARI APURBA

Dr. DEBASIS CHAKRABARTI

Abstract

ABSTRACT: PURPOSE– TO COMPARE THE EFFECT OF DAILY VS. ALTERNATE DAY THERAPY OF BIMATOPROST(0.01%) EYE DROPS IN DIAGNOSED CASES OF GLAUCOMA.

METHODS- THIRTY PATIENTS WITH DIAGNOSED GLAUCOMA IN BOTH EYE HAVE BEEN RANDOMLY GIVEN BIMATOPROST(0.01%) EYE DROPS ONCE DAILY IN ONE EYE AND ALTERNATE DAY IN THE OTHER EYE. CHANGE IN THE MEAN IOP AT 8.30A.M., 11.30 A.M. AND 1.45 P.M. WAS NOTED AND COMPARED WITH PRE TREATMENT IOP (BASELINE IOP IN BOTH EYE). MEASUREMENTS WERE TAKEN AT 2 WKS, 4 WKS, 8 WKS, 12 , 16 WKS AFTER TREATMENT.

RESULTS– AFTER 4 MONTHS OF TREATMENT, IOP REDUCTION IN EYE WITH DAILY THERAPY IS ( 5.5+- 0.5 MM HG (P VALUE < 0.001) AND EYE WHICH RECEIVED ALTERNATE DAY THERAPY -- AVERGE IOP REDUCTION IS ( 5.2 +- 0.5 MM HG) (P VALUE <0.001).BASELINE IOP IS(23+-0.5)MM HG. DIFFERENCE IN IOP LOWERING EFFECT IS NOTSTATISTICALLY SIGNIFICANT. CONCLUSION– ALTERNATE DAY THERAPY OF BIMATOPROST (0.01%) IS ALSO EFFECTIVE COMPARED TO ITS DAILY ADMINISTRATION IN CASES OF GLAUCOMA.

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