DR. RITIKA MULLICK

Dr. ROHIT SHETTY, Dr. POOJA KHAMAR

Abstract

PURPOSE: To study the changes in the corneal fibrillar distribution following corneal crosslinking (CXL) of keratoconus eyes

METHODS: 25 eyes of KC, 25 eyes pre and post-CXL were imaged with Polarisation Sensitive-OCT at 1,3,6 months. Scan of 11 mm diameter were captured; corneal fibril distribution images was generated using phase retardation (PR) maps. Eyes were imaged 3 times for repeatability.

RESULTS: Enface maps of KC eyes showed an abrupt change in preferential arrangement of collagen fibril structures. Binding of collagen fibrils appeared to be weak in KC eyes. This weak binding of collagen fibrils strengthened at 3 months post CXL and stabilized at 6 months with a relatively stronger binding as compared to preoperative arrangements.

CONCLUSION: Binding density of collagen fibrils improved and strengthened the cornea postoperatively. Posterior corneal PR maps can be used to track ultrastructure changes in collagen fibrils aiding in analysing effect of CXL procedure.

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